Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes
نویسندگان
چکیده
منابع مشابه
Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes
Elevated levels of the p53 protein occur in approximately 50% of human malignancies, which makes it an excellent target for a broad-spectrum T cell immunotherapy of cancer. A major barrier to the design of p53-specific immunotherapeutics and vaccines, however, is the possibility that T cells may be tolerant of antigens derived from wild-type p53 due to its low level of expression in normal thym...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1997
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.185.5.833